Open AccessDifferential response of the bvg virulence regulon of Bordetella pertussis to MgSO4 modulation
Author(s) -
Vincenzo Scarlato,
Rino Rappuoli
Publication year - 1991
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.173.22.7401-7404.1991
Subject(s) - bordetella pertussis , regulon , virulence , biology , filamentous haemagglutinin adhesin , adenylate cyclase toxin , promoter , locus (genetics) , microbiology and biotechnology , gene , pertussis toxin , genetics , regulation of gene expression , gene expression , signal transduction , bacteria , g protein
Magnesium sulfate is known to repress the expression of the virulence factors of Bordetella pertussis that are coordinately regulated by the bvg locus. We have tested the time required by MgSO4 to repress the synthesis of several bvg-regulated mRNA species and found that the promoters of the virulence genes (pertussis toxin, adenylate cyclase, and filamentous hemagglutinin) are repressed in 6 min, while the autogenously regulated promoters of the bvg locus (P1, P3, and P4) are repressed only several hours later. These data show a differential behavior between regulated and autoregulated genes of the bvg regulon.