Open AccessA single base pair change in proline biosynthesis genes causes osmotic stress tolerance
Author(s) -
Abhaya M. Dandekar,
Sandra L. Uratsu
Publication year - 1988
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.170.12.5943-5945.1988
Subject(s) - biology , proline , osmotic shock , escherichia coli , biosynthesis , biochemistry , osmotic pressure , gene , amino acid
A single base pair change has been found in a site corresponding to a regulatory region of the first enzyme in the proline biosynthetic pathway. This change alters feedback inhibition and is responsible for the synthesis of high levels of proline that enable Escherichia coli to withstand osmotic stress.