Open AccessPeroxisomal localization and activation by bivalent metal ions of ureidoglycolate lyase, the enzyme involved in urate degradation in Candida tropicalis
Author(s) -
Yoshikazu Takada,
N. Tsukiji
Publication year - 1987
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.169.5.2284-2286.1987
Subject(s) - candida tropicalis , bivalent (engine) , biology , enzyme , peroxisome , biochemistry , metal ions in aqueous solution , lyase , metal , yeast , chemistry , receptor , organic chemistry
Ureiodoglycolate lyase (EC 4.3.2.3) was found only in the peroxisomes in urate-induced Candida tropicalis. The enzyme was markedly activated by the bivalent metal ions Mn2+, Fe2+, and Ni2+. The activation by Mn2+ was suggested to be the result of its binding to the apoenzyme.