Open AccessMutations affecting expression and maintenance of genes encoding the serotype b capsule of Haemophilus influenzae
Author(s) -
Susan Ely,
J Tippett,
J. Simon Kroll,
E. Richard Moxon
Publication year - 1986
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.167.1.44-48.1986
Subject(s) - biology , haemophilus influenzae , serotype , gene , virulence , mutant , mutagenesis , genetics , bacterial capsule , gene duplication , microbiology and biotechnology , strain (injury) , virology , capsule , haemophilus , bacteria , anatomy , botany
Deletion mutagenesis analysis of a duplicated gene necessary for Haemophilus influenzae serotype b capsule expression showed that only one functional copy of this gene is required for capsule production and for virulence in infant rats. Mutant strains generated in this study differed from each other and from the parental strain in their ability to maintain the large tandem duplication which contains the genes involved in serotype b capsule expression.