Open AccessHeme Inhibition of Ferrisiderophore Reductase in Bacillus subtilis
Author(s) -
Jeff Lodge,
C G Gaines,
J. E. L. Arceneaux,
B. R. Byers
Publication year - 1982
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.152.2.943-945.1982
Subject(s) - bacillus subtilis , biology , heme , reductase , biochemistry , protoporphyrin ix , enzyme , bacteria , chemistry , genetics , photodynamic therapy , organic chemistry
Heme was a noncompetitive inhibitor (apparent K(i) and K'(i) = 0.043 mM) of a ferrisiderophore reductase purified from Bacillus subtilis; protoporphyrin IX had no effect. The cellular level of heme may partly regulate the function of this reductase to yield a controlled flow of iron into metabolism.