Open AccessEffect of a new pyrimidine analog on Bacillus subtilis growth
Author(s) -
Giovanni Raugei,
Marco Bazzicalupo,
Giorgio Federici,
Enzo Gallori,
Roberto Pepino,
M. Polsinelli
Publication year - 1981
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.145.2.1079-1081.1981
Subject(s) - bacillus subtilis , biology , pyrimidine , mutant , pyrimidine analogue , mutation , biochemistry , methylation , bacillaceae , genetics , dna , bacteria , gene
2-Amino-5-ethoxycarbonylpyrimidine-4(3H)-one, a pyrimidine analog, inhibited growth of Bacillus subtilis. Data were obtained which suggested that the analog interfered with the methylation process. A mutant resistant to the inhibitor was isolated, and the mutation was mapped.
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