Inactivation of the chemoattractant folic acid by cellular slime molds and identification of the reaction product
Author(s) -
P Pan,
Bernd Wurster
Publication year - 1978
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.136.3.955-959.1978
Subject(s) - dictyostelium discoideum , pterin , biology , chemotaxis , biochemistry , folic acid , mycetozoa , extracellular , slime mold , intracellular , enzyme , cofactor , receptor , medicine , gene
Enzymes inactivating the chemoattractants folic acid and pterin were detected in extracellular, intracellular, and particulate fractions obtained from Dictyostelium discoideum strains NC4 and AX-2 and Polysphondylium violaceum. The products of the inactivation reaction were analyzed by thin-layer chromatography and UV spectroscopy. Results obtained indicate that folic acid and pterin were deaminated to 2-deamino folic acid and lumazine, respectively.
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