Branched-chain amino acid transport regulation in mutants blocked in tRNA maturation and transcriptional termination | Zendy

Steven C. Quay | Zendy; Robert P. Lawther | Zendy; G. Wesley Hatfield | Zendy; Dale L. Oxender | Zendy

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Branched-chain amino acid transport regulation in mutants blocked in tRNA maturation and transcriptional termination

Author(s) -

Steven C. Quay,

Robert P. Lawther,

G. Wesley Hatfield,

Dale L. Oxender

Publication year - 1978

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.134.2.683-686.1978

Subject(s) - derepression , biology , transfer rna , leucine , mutant , transcription (linguistics) , biochemistry , pseudouridine , amino acid , antitermination , protein biosynthesis , escherichia coli , gene , structural gene , rna , operon , psychological repression , gene expression , linguistics , philosophy

The regulation of branched-chain amino acid transport and binding protein biosynthesis was studied in Escherichia coli strains containing hisT (the structural gene for pseudouridine synthetase) and rho (the structural gene for the mRNA transcriptional termination factor rho) mutations. The results indicate that the hisT strain cannot be fully derepressed for transport and that the hisT rho double mutant is partially derepressed under excess leucine conditions, but cannot be further derepressed by leucine deprivation. These data are consistent with a model in which fully mature tRNALeu is required for derepression and in which rho interacts with tRNALeu in regulating transport by terminating transcription, especially in excess-leucine growth conditions.

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