Open AccessGlutamine synthetase of Klebsiella aerogenes: properties of glnD mutants lacking uridylyltransferase
Author(s) -
F Foor,
Robert Cedergren,
S L Streicher,
Sue Goo Rhee,
Boris Magasanik
Publication year - 1978
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.134.2.562-568.1978
Subject(s) - glutamine synthetase , adenylylation , biology , enterobacter aerogenes , glutamine , mutant , biochemistry , mutation , klebsiella pneumoniae , enzyme , gene , microbiology and biotechnology , biosynthesis , escherichia coli , amino acid
The glnD mutation of Klebsiella aerogenes is cotransducible by phage P1 with pan (requirement for pantothenate) and leads to a loss of uridylytransferase and uridylyl-removing enzyme, components of the glutamine synthetase adenylylation system. This defect results in an inability to deadenylylate glutamine synthetase rapidly and in a requirement for glutamine for normal growth. Suppression of the glnD mutation are located at the glutamine synthetase structural gene glnA.
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