Dissociation of Lac Messenger Ribonucleic Acid Transcription from Translation During Recovery from Inhibition of Protein Synthesis | Zendy

Michael Artman | Zendy; Herbert L. Ennis | Zendy

Open Access

Dissociation of Lac Messenger Ribonucleic Acid Transcription from Translation During Recovery from Inhibition of Protein Synthesis

Author(s) -

Michael Artman,

Herbert L. Ennis

Publication year - 1972

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.110.2.652-660.1972

Subject(s) - puromycin , biology , messenger rna , protein biosynthesis , lac operon , chloramphenicol , transcription (linguistics) , operon , trp operon , translation (biology) , escherichia coli , biochemistry , microbiology and biotechnology , ribosome , rna , gene , antibiotics , linguistics , philosophy

Studies were made of the synthesis of Lac messenger ribonucleic acid (mRNA) byEscherichia coli in the absence of protein synthesis and of the coupling of transcription oflac operon to translation. Lac mRNA was not synthesized in the presence of chloramphenicol, and its synthesis steadily decreased during K+ deprivation and treatment with puromycin. Since under these conditions total mRNA synthesis is not inhibited it is suggested that the control of Lac mRNA is distinct from that which regulates total mRNA synthesis. Lac mRNA synthesized during recovery from K+ starvation or from chloramphenicol inhibition is not translated into functional enzyme, suggesting translational control over β-galactosidase synthesis.

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