Effect of Adenosine and Deoxyadenosine on the Incorporation and Breakdown of Thymidine in Escherichia coli K-12 | Zendy

Ezra Yagil | Zendy; Arie Rosner | Zendy

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Effect of Adenosine and Deoxyadenosine on the Incorporation and Breakdown of Thymidine in Escherichia coli K-12

Author(s) -

Ezra Yagil,

Arie Rosner

Publication year - 1970

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.103.2.417-421.1970

Subject(s) - phosphorolysis , deoxyadenosine , purine nucleoside phosphorylase , thymidine phosphorylase , thymidine , biology , purine , biochemistry , adenosine , escherichia coli , dna , nucleoside , thymine , nucleotide salvage , microbiology and biotechnology , nucleotide , enzyme , gene

Deoxyadenosine (AdR) and adenosine (AR) enhance the incorporation of thymidine (TdR) into bacterial deoxyribonucleic acid (DNA) by the inhibition of TdR phosphorolysis in vivo. Neither of the purine nucleosides has an effect on the reaction catalyzed by TdR phosphorylase in vitro. AdR induces TdR phosphorylase and both purine nucleosides induce purine nucleoside phosphorylase. AR can stimulate uptake of more TdR into bacterial DNA than AdR.

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