Open AccessThe Consistent Tick-Vertebrate Infectious Cycle of the Lyme Disease Spirochete Enables Borrelia burgdorferi To Control Protein Expression by Monitoring Its Physiological Status
Author(s) -
Brian Stevenson,
Andrew C Krusenstjerna,
Tatia. Castro-Padovani,
Christina R. Savage,
Brandon L. Jutras,
Timothy C. Saylor
Publication year - 2022
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00606-21
Subject(s) - biology , borrelia burgdorferi , lyme disease , spirochaetaceae , borrelia , virology , tick , ixodes , microbiology and biotechnology , lyme , immunology , antibody
The Lyme disease spirochete,Borrelia burgdorferi , persists in nature by alternatingly cycling between ticks and vertebrates. During each stage of the infectious cycle,B. burgdorferi produces surface proteins that are necessary for interactions with the tick or vertebrate tissues it encounters while also repressing the synthesis of unnecessary proteins.