YejM Controls LpxC Levels by Regulating Protease Activity of the FtsH/YciM Complex of Escherichia coli | Zendy

Daniel Nguyen | Zendy; Keilen M. Kelly | Zendy; Nan Qiu | Zendy; Rajeev Misra | Zendy

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YejM Controls LpxC Levels by Regulating Protease Activity of the FtsH/YciM Complex of Escherichia coli

Author(s) -

Daniel Nguyen,

Keilen M. Kelly,

Nan Qiu,

Rajeev Misra

Publication year - 2020

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00303-20

Subject(s) - biology , escherichia coli , protease , microbiology and biotechnology , biochemistry , enzyme , gene

Lipid homeostasis is critical for proper envelope functions. The level of LpxC, which catalyzes the first committed step of lipopolysaccharide (LPS) synthesis, is controlled by an essential protease complex comprised of FtsH and YciM. Work carried out here suggests YejM, an essential envelope protein, plays a central role in sensing the state of LPS synthesis and controls LpxC levels by regulating the activity of FtsH/YciM. All four essential proteins are attractive targets of therapeutic development.

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