Open AccessMeasurable Genomic Changes in Mycobacterium avium subsp. hominissuis after Long-Term Adaptation in Acanthamoeba lenticulata and Reduced Persistence in Macrophages
Author(s) -
Nabeeh A. Hasan,
Grant J. Norton,
Ravleen Virdi,
L. Elaine Epperson,
Charmie K. Vang,
Brandon Hellbusch,
Xiyuan Bai,
Edward D. Chan,
Michael Strong,
Jennifer R. Honda
Publication year - 2021
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00257-20
Subject(s) - biology , acanthamoeba , microbiology and biotechnology , mycobacterium , virulence , protozoa , virology , bacteria , genetics , gene
Short-term interaction between Acanthamoeba and M. avium has been demonstrated to increase infectivity in human and murine models of infection, establishing the paradigm that amoebae “train” M. avium in the environment by selecting for phenotypes capable of enduring in human cells. We investigated this phenomenon further by determining the consequence of long-term amoebae adaptation on M. avium subsp. hominissuis persistence in host cells.