Mutations in Ehrlichia chaffeensis Genes ECH_0660 and ECH_0665 Cause Transcriptional Changes in Response to Zinc or Iron Limitation | Zendy

Ascención Torres-Escobar | Zendy; María Dolores Juárez-Rodríguez | Zendy; Roman R. Ganta | Zendy

Open Access

Mutations in Ehrlichia chaffeensis Genes ECH_0660 and ECH_0665 Cause Transcriptional Changes in Response to Zinc or Iron Limitation

Author(s) -

Ascención Torres-Escobar,

María Dolores Juárez-Rodríguez,

Roman R. Ganta

Publication year - 2021

Publication title -

journal of bacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.652

H-Index - 246

eISSN - 1067-8832

pISSN - 0021-9193

DOI - 10.1128/jb.00027-21

Subject(s) - biology , ehrlichia chaffeensis , gene , mutant , microbiology and biotechnology , transcription (linguistics) , zinc finger , promoter , genetics , gene expression , transcription factor , polymerase chain reaction , linguistics , philosophy

Ehrlichia chaffeensis , a tick-transmitted bacterium, causes human monocytic ehrlichiosis by replicating within phagosomes of monocytes/macrophages. A function disruption mutation within the pathogen’s gene encoding a phage head-to-tail connector protein resulted in the rapid clearance of the pathogenin vivo , while aiding in induction of sufficient immunity in a host to protect against wild-type infection challenge.

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