Open AccessMutations in Ehrlichia chaffeensis Genes ECH_0660 and ECH_0665 Cause Transcriptional Changes in Response to Zinc or Iron Limitation
Author(s) -
Ascención Torres-Escobar,
María Dolores Juárez-Rodríguez,
Roman R. Ganta
Publication year - 2021
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.00027-21
Subject(s) - biology , ehrlichia chaffeensis , gene , mutant , microbiology and biotechnology , transcription (linguistics) , zinc finger , promoter , genetics , gene expression , transcription factor , polymerase chain reaction , linguistics , philosophy
Ehrlichia chaffeensis , a tick-transmitted bacterium, causes human monocytic ehrlichiosis by replicating within phagosomes of monocytes/macrophages. A function disruption mutation within the pathogen’s gene encoding a phage head-to-tail connector protein resulted in the rapid clearance of the pathogenin vivo , while aiding in induction of sufficient immunity in a host to protect against wild-type infection challenge.