Open AccessCytocidal and Apoptotic Effects of the ClyA Protein from Escherichia coli on Primary and Cultured Monocytes and Macrophages
Author(s) -
XinHe Lai,
Ignacio Arencibia,
Anders Johansson,
Sun Nyunt Wai,
Jan Oscarsson,
Sotirios Kalfas,
Kristina Sundqvist,
Yoshimitsu Mizunoe,
Anders Sjöstedt,
Bernt Eric Uhlin
Publication year - 2000
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.68.7.4363-4367.2000
Subject(s) - cytolysin , escherichia coli , biology , cytolysis , cytotoxic t cell , microbiology and biotechnology , enterobacteriaceae , cytotoxicity , apoptosis , in vitro , biochemistry , virulence , gene
Cytolysin A (ClyA) is a newly discovered cytolytic protein ofEscherichia coli K-12 that mediates a hemolytic phenotype. We show here that highly purified ClyA and ClyA-expressingE. coli were cytotoxic and apoptogenic to fresh as well as cultured human and murine monocytes/macrophages.