Proteophosphoglycan secreted by Leishmania mexicana amastigotes causes vacuole formation in macrophages | Zendy

Christopher M. Peters | Zendy; YorkDieter Stierhof | Zendy; Thomas Ilg | Zendy

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Proteophosphoglycan secreted by Leishmania mexicana amastigotes causes vacuole formation in macrophages

Author(s) -

Christopher M. Peters,

YorkDieter Stierhof,

Thomas Ilg

Publication year - 1997

Publication title -

infection and immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.508

H-Index - 220

eISSN - 1070-6313

pISSN - 0019-9567

DOI - 10.1128/iai.65.2.783-786.1997

Subject(s) - amastigote , biology , leishmania mexicana , vacuole , secretion , macrophage , leishmania , microbiology and biotechnology , intracellular , phagosome , vacuolization , phagolysosome , in vitro , cytoplasm , biochemistry , parasite hosting , endocrinology , world wide web , computer science

The amastigote form of Leishmania mexicana parasites colonizes macrophage phagolysosomes and induces the enlargement of these compartments to form huge parasitophorous vacuoles. We report here that a purified secreted amastigote product, proteophosphoglycan, is a macromolecule which causes vacuolization of peritoneal macrophages in vitro. Secretion of this glycoconjugate by intracellular parasites may contribute to the expansion of phagolysosomal compartments in infected cells.

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