Open AccessRole of complement in viral infections: participation of terminal complement components (C5 to C9) in recovery of mice from Sindbis virus infection
Author(s) -
Robert Hirsch,
Diane E. Griffin,
Jerry A. Winkelstein
Publication year - 1980
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.30.3.899-901.1980
Subject(s) - sindbis virus , biology , congenic , pathogenesis , complement (music) , virology , virus , complement system , complement component 5 , immunology , antibody , genetics , gene , rna , complementation , phenotype
the pathogenesis of Sindbis virus infection was studied in congenic mice with normal levels of the fifth component of complement (C5) and in mice deficient in C5. Mice deficient in C5 had a higher mortality rate than mice with normal levels of C5 as well as impaired clearance of virus from their brain and feet.