Open AccessEffects of treatment with muramyl dipeptide and certain of its analogs on resistance to Listeria monocytogenes in mice
Author(s) -
R C Humphres,
Philip R. Henika,
R. W. Ferraresi,
James L. Krahenbuhl
Publication year - 1980
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.30.2.462-466.1980
Subject(s) - muramyl dipeptide , listeria monocytogenes , streptococcus pneumoniae , listeria , microbiology and biotechnology , listeria infection , biology , adjuvant , ratón , pneumococcal infections , antibiotics , immunology , bacteria , immune system , genetics
Studies were carried out to determine whether treatment of mice with the synthetic adjuvant muramyl dipeptide (MDP) afforded any resistance to infection with Listeria monocytogenes. Regardless of the timing, dose, or route of administration, there was no evidence that treatment with either MDP or two of its analogs (des-MDP or MDP-D-D) induced any resistance to listeria infection in BALB/c, CBA/J, or C57BL/6J mice. In contrast, pretreatment with MDP induced marked protection to infection with Streptococcus pneumoniae (type III).