Open AccessDifferent secretory immunoglobulin A antibody responses to cholera vaccination in Swedish and Pakistani women
Author(s) -
A. M. Svennerholm,
Lars Å. Hanson,
Jan Holmgren,
B. S. Lindblad,
B Nilsson,
F. Quereshi
Publication year - 1980
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.30.2.427-430.1980
Subject(s) - cholera vaccine , saliva , antibody , immunoglobulin a , immunology , vaccination , cholera , titer , booster dose , antibody titer , biology , immunoglobulin g , immunization , vibrio cholerae , virology , medicine , biochemistry , bacteria , genetics
The capacity of subcutaneous cholera vaccination to induce an antibody response in milk and saliva was studied in lactating Swedish and Pakistani women, since secretory immunoglobulin A (SIgA) antibody responses in these secretions may reflect intestinal immunity. Before immunization, most of the Pakistani women had significant titers of specific SIgA antibodies against Vibrio cholerae lipopolysaccharide in milk, whereas only a few of the Swedish women had measurable, low titers. In the Pakistani women a single subcutaneous injection of cholera vaccine gave rise to a significant SIgA titer rise in 70% of the milk and 45% of the saliva samples. The Swedish women, on the other hand, did not respond with a significant antibody response of any immunoglobulin class in milk or saliva, either after a single or after a booster dose 14 days later. In serum, however, the vaccination induced significant titer rises, mainly of IgG antibodies, also in the Swedish women, but these rises were of lower magnitude than those in the Pakistani group. The results suggest a significant difference in the capacity of parenterally administered cholera vaccine to stimulate SIgA antibody formation in naturally primed and nonprimed individuals.