Open AccessMitogenic activity of staphylococcal exfoliative toxin
Author(s) -
Beverly A. Morlock,
Leonard Spero,
Anna D. Johnson
Publication year - 1980
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.30.2.381-384.1980
Subject(s) - staphylococcus aureus , biology , enterotoxin , toxin , microbiology and biotechnology , spleen , staphylococcal infections , immunology , bacteria , escherichia coli , biochemistry , genetics , gene
Exfoliative toxin from Staphylococcus aureus was mitogenic for murine spleen cells. It was primarily active on T lymphocytes but also significantly stimulated B cells from the spleens of nude mice. The mitogenicity was not affected by simple sugar or alpha-methylpyranosides. N-acetylglucosamine and N-acetylgalactosamine inhibited its effect. Exfoliatin was as powerful a mitogen as the enterotoxins of S. aureus. Some significant differences between the mitogenic activity of the two toxins were demonstrated.