Open AccessInteractions between murine alveolar macrophages and Mycoplasma pulmonis in vitro
Author(s) -
J. K. Davis,
K M Delozier,
Durga Bhavani A K,
F. Chris Minion,
Gail H. Cassell
Publication year - 1980
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.29.2.590-599.1980
Subject(s) - biology , in vitro , microbiology and biotechnology , antibody , mycoplasma , macrophage , pulmonary alveolus , cytotoxic t cell , alveolar macrophage , immunology , biochemistry
In comparison to syngeneic fibroblasts, alveolar macrophages collected from Fischer 344 rats demonstrated a significant ability to decrease the growth rate of cell-associated Mycoplasma pulmonis, even in the absence of specific actimycoplasmal antibodies. However, when exposed to thallium acetate (a cytotoxic heavy metal), macrophages supported growth of mycoplasmas almost as well as did untreated fibroblasts. This suggests an active antimycoplasmal process operative in untreated macrophages. In contrast, mouse alveolar macrophages were not capable of exerting an antimycoplasmal effect unless rabbit anti-M. pulmonis antibodies were present. Paradoxically, mouse anti-M. pulmonis antibodies did not promote this effect.