Open AccessProtection of Mice Against Bacterial Infection by Interferon Inducers
Author(s) -
Frank F. Pindak
Publication year - 1970
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.1.3.271-273.1970
Subject(s) - interferon , biology , klebsiella pneumoniae , microbiology and biotechnology , inducer , inoculation , virus , virology , persistence (discontinuity) , immunology , escherichia coli , biochemistry , gene , geotechnical engineering , engineering
Antibacterial effect of known interferon inducers was investigated. Intraperitoneal injection of statolon or pyran markedly enhanced the survival of mice challenged with Klebsiella pneumoniae. The sparing effect of these two interferon inducers resembled that of bacterial endotoxin. Significant protection was obtained when the inducers were administered 24 hr before challenge. Treatments given 6 hr before or at the time of infection were ineffective. The persistence of increased resistance of treated animals to encephalomyocarditis virus strain MM, inoculated 5 days after challenge with K. pneumoniae, indicated that the bacterial infection did not adversely influence the induction or effectiveness of interferon.