Open AccessEnhanced Toxicity of Nervous System Drugs for Germ-Free Mice
Author(s) -
Carl Lamanna,
Thomas G. Ward
Publication year - 1970
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.1.2.139-141.1970
Subject(s) - picrotoxin , pentobarbital , pharmacology , strychnine , atropine , barbital , biology , nervous system , toxicity , histamine , medicine , endocrinology , biochemistry , neuroscience , receptor , antagonist
Germ-free mice were found to be more sensitive than conventional mice to poisoning by hemicholinium-3, hexamethonium chloride, strychnine sulfate, sodium pentobarbital, sodium barbital, and histamine diphosphate. On the other hand, conventional mice were more sensitive to atropine. No difference between germ-free and conventional mice was found in sensitivity to d-tubocurarine, metrazol, and picrotoxin. These findings raise a question as to the influence of exposure to microorganisms in the development of sensitivity to drugs acting on the nervous system.