Open AccessStrategic Variants of CSP Delivered as SynDNA Vaccines Demonstrate Heterogeneity of Immunogenicity and Protection from Plasmodium Infection in a Murine Model
Author(s) -
Sophia M. Reeder,
Mamadou A. Bah,
Nicholas J. Tursi,
Rebekah Brooks,
Ami Patel,
Rianne Esquivel,
Alison Eaton,
Hugo Jhun,
Jacqueline D. Chu,
Kevin Kim,
Ziyang Xu,
Fidel Zavala,
David B. Weiner
Publication year - 2021
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00728-20
Subject(s) - circumsporozoite protein , immunogenicity , biology , malaria , virology , vaccination , plasmodium (life cycle) , immunity , plasmodium falciparum , malaria vaccine , disease eradication , immunology , disease , immune system , parasite hosting , medicine , pathology , world wide web , computer science
Malaria infects millions of people every year, and despite recent advances in controlling disease spread, such as vaccination, it remains a global health concern. The circumsporozoite protein (CSP) has long been acknowledged as a key target in antimalarial immunity.
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