Open AccessStrategic Variants of CSP Delivered as SynDNA Vaccines Demonstrate Heterogeneity of Immunogenicity and Protection from Plasmodium Infection in a Murine Model
Author(s) -
Sophia Reeder,
M. Bah,
Nicholas J. Tursi,
Rebekah Brooks,
Ami Patel,
Rianne N. Esquivel,
Alison Eaton,
Hugo Jhun,
Jacqueline Chu,
Kevin Kim,
Ziyang Xu,
Fidel Zavala,
David B. Weiner
Publication year - 2021
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00728-20
Subject(s) - immunogenicity , virology , biology , malaria vaccine , malaria , parasitemia , immunity , circumsporozoite protein , vaccination , antibody , antigen , dna vaccination , monoclonal antibody , humoral immunity , immunology , plasmodium falciparum , immune system , immunization
Malaria infects millions of people every year, and despite recent advances in controlling disease spread, such as vaccination, it remains a global health concern. The circumsporozoite protein (CSP) has long been acknowledged as a key target in antimalarial immunity.