Open AccessIntranasal Immunization with Acellular Pertussis Vaccines Results in Long-Term Immunity to Bordetella pertussis in Mice
Author(s) -
Maximilian Wolf,
Dylan T. Boehm,
Megan A. DeJong,
Ting Y. Wong,
Emel Sen-Kilic,
Joseph Hall,
Catherine B. Blackwood,
Kelly Weaver,
Claire O. Kelly,
Caleb A. Kisamore,
Graham J. Bitzer,
Justin R. Bevere,
Mariette Barbier,
F. Heath Damron
Publication year - 2021
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00607-20
Subject(s) - bordetella pertussis , immunity , immunology , whooping cough , biology , immunization , respiratory tract , bordetella , pathogen , immune system , pertussis vaccine , virology , microbiology and biotechnology , respiratory system , vaccination , bacteria , genetics , anatomy
Bordetella pertussis colonizes the respiratory mucosa of humans, inducing an immune response seeded in the respiratory tract. An individual, once convalescent, exhibits long-term immunity to the pathogen.