Open AccessMcc1229, an Stx2a-Amplifying Microcin, Is Produced In Vivo and Requires CirA for Activity
Author(s) -
Erin M. Nawrocki,
Laura Hutchins,
Kathryn A. Eaton,
Edward G. Dudley
Publication year - 2022
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00587-21
Subject(s) - biology , microbiology and biotechnology , escherichia coli , plasmid , orfs , prophage , periplasmic space , subcloning , mutant , gene , open reading frame , bacteriophage , genetics , peptide sequence
EnterohemorrhagicEscherichia coli (EHEC) strains, including the foodborne pathogenE. coli O157:H7, are responsible for thousands of hospitalizations each year. Various environmental triggers can modulate pathogenicity in EHEC by inducing the expression of Shiga toxin (Stx), which is encoded on a lambdoid prophage and transcribed together with phage late genes.