Open AccessType VI Secretion System and Its Effectors PdpC, PdpD, and OpiA Contribute to Francisella Virulence in Galleria mellonella Larvae
Author(s) -
Maj Brodmann,
Sophie T. Schnider,
Marek Basler
Publication year - 2021
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00579-20
Subject(s) - galleria mellonella , francisella tularensis , francisella , tularemia , biology , type vi secretion system , virulence , microbiology and biotechnology , effector , virulence factor , secretion , virology , genetics , gene , biochemistry
Francisella tularensis causes the deadly zoonotic disease tularemia in humans and is able to infect a broad range of organisms including arthropods, which are thought to play a major role inFrancisella transmission. However, while mammalianin vitro andin vivo infection models are widely used to investigateFrancisella pathogenicity, a detailed characterization of the majorFrancisella virulence factor, a noncanonical type VI secretion system (T6SS), in an arthropodin vivo infection model is missing.