Open AccessThe Pseudomonas aeruginosa Type III Secretion System Exoenzyme Effector ExoU Induces Mitochondrial Damage in a Murine Bone Marrow-Derived Macrophage Infection Model
Author(s) -
Kierra S. Hardy,
Amanda N. Tuckey,
Nicole A. Housley,
Joel Andrews,
Mita Patel,
AbuBakr AlMehdi,
Robert A. Barrington,
Suzanne L. Cassel,
Fayyaz S. Sutterwala,
Jonathon P. Audia
Publication year - 2022
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00470-21
Subject(s) - pseudomonas aeruginosa , biology , microbiology and biotechnology , effector , secretion , type three secretion system , macrophage , pathogen , exoenzyme , virulence , pneumonia , pathogenesis , immunology , bacteria , in vitro , medicine , biochemistry , genetics , gene
Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that causes nosocomial pneumonia, urinary tract infections, and bacteremia. A hallmark ofP. aeruginosa pathogenesis is disruption of host cell function by the type III secretion system (T3SS) and its cognate exoenzyme effectors.