Open AccessDistinct Serotypes of Streptococcal M Proteins Mediate Fibrinogen-Dependent Platelet Activation and Proinflammatory Effects
Author(s) -
Frida Palm,
Sounak Chowdhury,
Sara Wettemark,
Johan Malmström,
Lotta Happonen,
Oonagh Shan
Publication year - 2022
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00462-21
Subject(s) - proinflammatory cytokine , biology , fibrinogen , serotype , platelet , platelet activation , immunology , streptococcus pyogenes , microbiology and biotechnology , streptococcal infections , inflammation , bacteria , biochemistry , genetics , staphylococcus aureus
Sepsis is a life-threatening complication of infection that is characterized by a dysregulated inflammatory state and disturbed hemostasis. Platelets are the main regulators of hemostasis, and they also respond to inflammation.