Open AccessMice Lacking γδ T Cells Exhibit Impaired Clearance of Pseudomonas aeruginosa Lung Infection and Excessive Production of Inflammatory Cytokines
Author(s) -
Toka Omar,
Pascal Ziltener,
Erin Chamberlain,
Zhenyu Cheng,
Brent Johnston
Publication year - 2020
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00171-20
Subject(s) - pseudomonas aeruginosa , biology , immune system , innate immune system , immunity , lung , immunology , microbiology and biotechnology , pathogen , chronic infection , opportunistic pathogen , inflammation , proinflammatory cytokine , bacteria , medicine , genetics
Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic and life-threatening infections in immunocompromised patients. A better understanding of the role that innate immunity plays in the control of P. aeruginosa infection is crucial for therapeutic development. Specifically, the role of unconventional immune cells like γδ T cells in the clearance of P. aeruginosa lung infection is not yet well characterized.