Open AccessA Small Membrane Stabilizing Protein Critical to the Pathogenicity of Staphylococcus aureus
Author(s) -
Seána Duggan,
Maisem Laabei,
Alaa A.M. Al-Nahari,
Eóin C. O’Brien,
Keenan A. Lacey,
Leann Bacon,
Kate J. Heesom,
Chih-Lung Fu,
Michael Otto,
Eric P. Skaar,
Rachel M. McLoughlin,
Ruth C. Massey
Publication year - 2020
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00162-20
Subject(s) - staphylococcus aureus , biology , pathogen , virulence , microbiology and biotechnology , antibiotics , pathogenicity , human pathogen , staphylococcal infections , bacteria , gene , genetics
Staphylococcus aureus is a major human pathogen, and the emergence of antibiotic-resistant strains is making all types of S. aureus infections more challenging to treat. With a pressing need to develop alternative control strategies to use alongside or in place of conventional antibiotics, one approach is the targeting of established virulence factors. However, attempts at this have had little success to date, suggesting that we need to better understand how this pathogen causes disease if effective targets are to be identified.