Open AccessDynamic Pneumococcal Genetic Adaptations Support Bacterial Growth and Inflammation during Coinfection with Influenza
Author(s) -
Amanda Smith,
Lindey C. Lane,
Tim van Opijnen,
Stacie Woolard,
Caroline Robert,
Amy Iverson,
Corinna Burnham,
Peter Vogel,
Dana Roeber,
Gabrielle Hochu,
Michael D. L. Johnson,
Jonathan A. McCullers,
Jason Rosch,
Amber M. Smith
Publication year - 2021
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00023-21
Subject(s) - biology , coinfection , streptococcus pneumoniae , inflammation , pneumococcal infections , microbiology and biotechnology , immunology , virology , antibiotics , virus
Streptococcus pneumoniae (pneumococcus) is one of the primary bacterial pathogens that complicates influenza virus infections. These bacterial coinfections increase influenza-associated morbidity and mortality through a number of immunological and viral-mediated mechanisms, but the specific bacterial genes that contribute to postinfluenza pathogenicity are not known.