Open AccessTumor Necrosis Factor Alpha Contributes to Inflammatory Pathology in the Placenta during Brucella abortus Infection
Author(s) -
April Y. Tsai,
Mariana X. Byndloss,
Núbia Seyffert,
Maria G. Winter,
Benjamin E. Young,
Renée M. Tsolis
Publication year - 2022
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00013-22
Subject(s) - biology , brucella abortus , tumor necrosis factor alpha , brucellosis , placenta , necrosis , brucella , immunology , pathology , alpha (finance) , inflammation , microbiology and biotechnology , pregnancy , medicine , fetus , genetics , construct validity , nursing , patient satisfaction
Research onBrucella pathogenesis has focused primarily on its ability to cause persistent intracellular infection of the mononuclear phagocyte system. At these sites,Brucella abortus evades innate immunity, which results in low-level inflammation and chronic infection of phagocytes.