Open AccessConvergent Evolution of Antibiotic Tolerance in Patients with Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia
Author(s) -
Mitra Maria Elgrail,
Edwin Chen,
Marla G Shaffer,
Vatsala Rangachar Srinivasa,
M. Patrick Griffith,
Mustapha M. Mustapha,
Ryan K. Shields,
Daria Van Tyne,
Matthew J. Culyba
Publication year - 2022
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00001-22
Subject(s) - bacteremia , staphylococcus aureus , antibiotics , methicillin resistant staphylococcus aureus , microbiology and biotechnology , antibiotic resistance , staphylococcal infections , biology , multidrug tolerance , drug resistance , micrococcaceae , antibacterial agent , bacteria , biofilm , genetics
Severe infections caused by methicillin-resistantStaphylococcus aureus (MRSA) are often complicated by persistent bacteremia (PB) despite active antibiotic therapy. Antibiotic resistance rarely contributes to MRSA-PB, suggesting an important role for antibiotic tolerance pathways.