Open AccessDraft Genome Sequence of a Metronidazole-Resistant Derivative of Gardnerella vaginalis Strain ATCC 14019
Author(s) -
Jessica A. Schuyler,
Eli Mordechai,
Martin E. Adelson,
Scott E. Gygax,
David W. Hilbert
Publication year - 2015
Publication title -
genome announcements
Language(s) - English
Resource type - Journals
ISSN - 2169-8287
DOI - 10.1128/genomea.01345-15
Subject(s) - gardnerella vaginalis , whole genome sequencing , metronidazole , biology , strain (injury) , gene , microbiology and biotechnology , genome , genetics , antibiotics , anatomy , bacterial vaginosis
We report the genome sequence of a metronidazole-resistant derivative of Gardnerella vaginalis ATCC 14019. This strain was obtained after serial selection to increase the MIC from 4 to ≥500 µg/ml. Two coding changes, in genes encoding a response regulator and an NAD(+) synthetase, arose during selection.