Open AccessDraft Genome Sequences of Clinical Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Strain APS211 and Its Daptomycin-Susceptible Progenitor APS210
Author(s) -
David R. Cameron,
Jhih-Hang Jiang,
Iain J. Abbott,
Denis Spelman,
Anton Y. Peleg
Publication year - 2015
Publication title -
genome announcements
Language(s) - English
Resource type - Journals
ISSN - 2169-8287
DOI - 10.1128/genomea.00568-15
Subject(s) - daptomycin , staphylococcus aureus , biology , strain (injury) , microbiology and biotechnology , whole genome sequencing , genome , gene , genetics , bacteria , vancomycin , anatomy
To assess the genetic factors contributing to daptomycin resistance in Staphylococcus aureus, the draft genome of a clinically derived daptomycin-nonsusceptible isolate APS211 was generated and compared to the draft sequence of its susceptible progenitor strain APS210. Four genetic differences were identified including a previously described mutation within the mprF gene.