Open AccessEvidence of Clonal Expansion in the Genome of a Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolate from Peru
Author(s) -
Marco Galarza,
David Tarazona,
Víctor Borda,
Juan Agapito,
Heinner Guio
Publication year - 2014
Publication title -
genome announcements
Language(s) - English
Resource type - Journals
ISSN - 2169-8287
DOI - 10.1128/genomea.00089-14
Subject(s) - rpob , biology , multiple drug resistance , whole genome sequencing , mycobacterium tuberculosis , lineage (genetic) , genome , strain (injury) , tuberculosis , gene , drug resistance , genetics , virology , microbiology and biotechnology , medicine , pathology , 16s ribosomal rna , anatomy
We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDR-TB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R) genes. Our evidence suggests that INS-MDR may be a clonal expansion related to the African strain KZN 1435.