Open AccessCharacterization of a Molecular Chaperone Present in the Eukaryotic Flagellum
Author(s) -
Jessica Shapiro,
Jessica R. Ingram,
Karl A. Johnson
Publication year - 2005
Publication title -
eukaryotic cell
Language(s) - English
Resource type - Journals
eISSN - 1535-9778
pISSN - 1535-9786
DOI - 10.1128/ec.4.9.1591-1594.2005
Subject(s) - flagellum , chaperone (clinical) , biology , chlamydomonas , cytoplasm , microbiology and biotechnology , intraflagellar transport , chlamydomonas reinhardtii , motor protein , kinesin , molecular motor , transport protein , cilium , molecular machine , genetics , microtubule , gene , medicine , pathology , mutant
Chlamydomonas flagella contain a molecular chaperone now identified as HSP70A, a major cytoplasmic isoform. HSP70A synthesis is upregulated by deflagellation, and its distribution in the flagellum overlaps with the IFT kinesin-II motor FLA10. HSP70A may chaperone flagellar proteins during transport, participating in the assembly and maintenance of the flagellum.