Open AccessThe Parasitophorous Vacuole Membrane ofEncephalitozoon cuniculiLacks Host Cell Membrane Proteins Immediately after Invasion
Author(s) -
Verena Fasshauer,
Uwe Groß,
Wolfgang Bohne
Publication year - 2005
Publication title -
eukaryotic cell
Language(s) - English
Resource type - Journals
eISSN - 1535-9778
pISSN - 1535-9786
DOI - 10.1128/ec.4.1.221-224.2005
Subject(s) - biology , endoplasmic reticulum , encephalitozoon cuniculi , endosome , endocytic cycle , vacuole , microbiology and biotechnology , colocalization , lysosome , membrane protein , endocytosis , microsporidia , biochemistry , cell , membrane , intracellular , cytoplasm , spore , enzyme
Microsporidia of the genus Encephalitozoon develop inside a parasitophorous vacuole (PV) of unknown origin. Using colocalization studies, the PV was found to be absent from the endocytic pathway markers early endosomal autoantigen 1, transferrin receptor, and lysosome-associated membrane protein 1 and for the endoplasmic reticulum marker calnexin. The nonfusiogenic characteristic of the PV appears to be acquired as early as 1 min postinfection and is not reversed by drug treatment with albendazole or fumagillin.