Open AccessSte12 and Ste12-Like Proteins, Fungal Transcription Factors Regulating Development and Pathogenicity
Author(s) -
Joanne Wong Sak Hoi,
Bernard Dumas
Publication year - 2010
Publication title -
eukaryotic cell
Language(s) - English
Resource type - Journals
eISSN - 1535-9778
pISSN - 1535-9786
DOI - 10.1128/ec.00333-09
Subject(s) - biology , transcription factor , saccharomyces cerevisiae , gene , yeast , genetics , fungal protein , regulation of gene expression
Ste12 and Ste12-like proteins are transcription factors found exclusively in the fungal kingdom. In the yeast modelSaccharomyces cerevisiae , where the first member was identified, Ste12p was shown to regulate mating and invasive/pseudohyphal growth. In recent literature, there have been several reports of Ste12-like factors in multiple fungal systems, yeasts or filamentous fungi, with saprophytic or parasitic life-styles. In all these models, Ste12 and Ste12-like factors are involved in the regulation of fungal development and pathogenicity. In this review, we discuss the features, the regulation, and the role of Ste12 and Ste12-like factors by highlighting the similarities and dissimilarities that occur within this group.