Open AccessInteraction between the Candida albicans High-Osmolarity Glycerol (HOG) Pathway and the Response to Human β-Defensins 2 and 3
Author(s) -
Silvia Argimón,
Saranna Fanning,
Jill R. Blankenship,
Aaron P. Mitchell
Publication year - 2011
Publication title -
eukaryotic cell
Language(s) - English
Resource type - Journals
eISSN - 1535-9778
pISSN - 1535-9786
DOI - 10.1128/ec.00133-10
Subject(s) - candida albicans , defensin , biology , microbiology and biotechnology , osmotic concentration , mutant , beta defensin , glycerol , antimicrobial peptides , human pathogen , peptide , antimicrobial , pathogen , fungal pathogen , biochemistry , gene
Human β-defensins 2 and 3 are small cationic peptides with antimicrobial activity against the fungal pathogenCandida albicans . We found thathog1 andpbs2 mutants were hypersensitive to treatment with these peptides, pointing to a role of the high-osmolarity glycerol (HOG) pathway in the response to defensin-induced cell injury.