Interaction between the Candida albicans High-Osmolarity Glycerol (HOG) Pathway and the Response to Human β-Defensins 2 and 3 | Zendy

Silvia Argimón | Zendy; Saranna Fanning | Zendy; Jill R. Blankenship | Zendy; Aaron P. Mitchell | Zendy

Open Access

Interaction between the Candida albicans High-Osmolarity Glycerol (HOG) Pathway and the Response to Human β-Defensins 2 and 3

Author(s) -

Silvia Argimón,

Saranna Fanning,

Jill R. Blankenship,

Aaron P. Mitchell

Publication year - 2010

Publication title -

eukaryotic cell

Language(s) - English

Resource type - Journals

eISSN - 1535-9778

pISSN - 1535-9786

DOI - 10.1128/ec.00133-10

Subject(s) - candida albicans , defensin , biology , microbiology and biotechnology , osmotic concentration , mutant , beta defensin , glycerol , antimicrobial peptides , human pathogen , peptide , antimicrobial , pathogen , fungal pathogen , biochemistry , gene

Human β-defensins 2 and 3 are small cationic peptides with antimicrobial activity against the fungal pathogenCandida albicans . We found thathog1 andpbs2 mutants were hypersensitive to treatment with these peptides, pointing to a role of the high-osmolarity glycerol (HOG) pathway in the response to defensin-induced cell injury.

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