Association of Serotype-Specific Antibody Concentrations and Functional Antibody Titers with Subsequent Pneumococcal Carriage in Toddlers Immunized with a 9-Valent Pneumococcal Conjugate Vaccine | Zendy

Birgit Simell | Zendy; Anu Nurkka | Zendy; Mika Lahdenkari | Zendy; Noga GivonLavi | Zendy; Helena Käyhty | Zendy; Ron Dagan | Zendy; Jukka Jokinen | Zendy

Open Access

Association of Serotype-Specific Antibody Concentrations and Functional Antibody Titers with Subsequent Pneumococcal Carriage in Toddlers Immunized with a 9-Valent Pneumococcal Conjugate Vaccine

Author(s) -

Birgit Simell,

Anu Nurkka,

Mika Lahdenkari,

Noga GivonLavi,

Helena Käyhty,

Ron Dagan,

Jukka Jokinen

Publication year - 2011

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.05369-11

Subject(s) - serotype , carriage , pneumococcal conjugate vaccine , titer , antibody , streptococcus pneumoniae , virology , immunization , pneumococcal infections , medicine , conjugate , immunology , microbiology and biotechnology , biology , antibiotics , pathology , mathematical analysis , mathematics

Association of pneumococcal nasopharyngeal carriage with the concentration and opsonophagocytic activity (OPA) of serum serotype-specific antibodies was determined for toddlers 1 month after immunization with a 9-valent pneumococcal conjugate vaccine. Higher anti-serotype 14 and anti-serotype 19F IgG and anti-serotype 14 IgM correlated with a lowered probability of pneumococcal acquisition. Postvaccination OPA did not correlate with pneumococcal carriage.

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