Protective Effects of Passively Transferred Merozoite-Specific Antibodies against Theileria equi in Horses with Severe Combined Immunodeficiency | Zendy

Robert H. Mealey | Zendy; Lowell S. Kappmeyer | Zendy; Massaro W. Ueti | Zendy; Bettina Wagner | Zendy; Donald P. Knowles | Zendy

Open Access

Protective Effects of Passively Transferred Merozoite-Specific Antibodies against Theileria equi in Horses with Severe Combined Immunodeficiency

Author(s) -

Robert H. Mealey,

Lowell S. Kappmeyer,

Massaro W. Ueti,

Bettina Wagner,

Donald P. Knowles

Publication year - 2011

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.05301-11

Subject(s) - virology , antibody , immunodeficiency , immunology , medicine , human immunodeficiency virus (hiv) , biology , immune system

Theileria equi immune plasma was infused into young horses (foals) with severe combined immunodeficiency. Although all foals became infected following intravenous challenge with homologousT. equi merozoite stabilate, delayed time to peak parasitemia occurred. Protective effects were associated with a predominance of passively transferred merozoite-specific IgG3.

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