Open AccessThe Signal Peptide Sequence Impacts the Immune Response Elicited by a DNA Epitope Vaccine
Author(s) -
Dimitrios N. Vatakis,
Minnie McMillan
Publication year - 2011
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.05179-11
Subject(s) - immunogenicity , epitope , dna vaccination , chemokine , immune system , virology , dna , biology , signal peptide , peptide sequence , transmembrane protein , computational biology , sequence (biology) , antibody , plasmid , immunology , genetics , gene , receptor
We examined the effect of two leader sequences, one from a transmembrane molecule (H2-L d ) and another from a secreted molecule (rat KC chemokine), on the immunogenicity of DNA epitope vaccines. The chemokine leader enhanced vaccine immunogenicity, thus underscoring the importance of the leader sequence in DNA epitope vaccine design.