Open AccessSubcutaneous Immunization with Baculovirus Surface-Displayed Hemagglutinin of Pandemic H1N1 Influenza A Virus Induces Protective Immunity in Mice
Author(s) -
Mookkan Prabakaran,
Tao Meng,
Fang He,
Yunrui Tan,
Qiang Jia,
Raymond Tzer Pin Lin,
Jimmy Kwang
Publication year - 2011
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cvi.05114-11
Subject(s) - virology , hemagglutinin (influenza) , virus , immunity , immunization , influenza a virus , biology , pandemic , antibody , immune system , immunology , medicine , covid-19 , infectious disease (medical specialty) , disease , pathology
The protective immunity of baculovirus displaying influenza virus hemagglutinin (BacHA) against influenza 2009 H1N1 virus infection in a murine model was investigated. The results showed that mice vaccinated with live BacHA or an inactive form of adjuvanted BacHA had enhanced specific antibody responses and induced protective immunity against 2009 H1N1 virus infection, suggesting the potential of baculovirus as a live or inactivated vaccine.