Adeno-Associated Virus Antibody Profiles in Newborns, Children, and Adolescents | Zendy

Roberto Calcedo | Zendy; Hiroki Morizono | Zendy; Lili Wang | Zendy; Robert McCarter | Zendy; Jianping He | Zendy; David Jones | Zendy; Mark L. Batshaw | Zendy; James M. Wilson | Zendy

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Adeno-Associated Virus Antibody Profiles in Newborns, Children, and Adolescents

Author(s) -

Roberto Calcedo,

Hiroki Morizono,

Lili Wang,

Robert McCarter,

Jianping He,

David Jones,

Mark L. Batshaw,

James M. Wilson

Publication year - 2011

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.05107-11

Subject(s) - adeno associated virus , serotype , antibody , virology , virus , titer , medicine , neutralizing antibody , antibody titer , immunology , biology , vector (molecular biology) , gene , genetics , recombinant dna

Neutralizing antibodies (NAb) to an adeno-associated virus (AAV) vector due to previous natural infection with wild-type AAV can significantly limit gene transfer. NAb titers to AAV serotype 2 (AAV2) and AAV8 in human subjects (0 to 18 years) were studied. NAb prevalence is moderate at birth, decreases markedly from 7 to 11 months, and then progressively increases through childhood and adolescence.

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