Interaction between Endogenous Bacterial Flora and Latent HIV Infection | Zendy

Ann Florence B. Victoriano | Zendy; Kenichi Imai | Zendy; Takashi Okamoto | Zendy

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Interaction between Endogenous Bacterial Flora and Latent HIV Infection

Author(s) -

Ann Florence B. Victoriano,

Kenichi Imai,

Takashi Okamoto

Publication year - 2013

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00766-12

Subject(s) - bacteria , biology , flora (microbiology) , virus latency , endogeny , microbiology and biotechnology , latency (audio) , immunology , virology , viral replication , human immunodeficiency virus (hiv) , virus , genetics , engineering , electrical engineering , endocrinology

Human commensal bacteria do not normally cause any diseases. However, in certain pathological conditions, they exhibit a number of curious behaviors. In HIV infection, these bacteria exhibit bidirectional relationships: whereas they cause opportunistic infections based on immunological deterioration, they also augment HIV replication, in particular, viral replication from latently infected cells, which is attributable to the effect of butyric acid produced by certain anaerobic bacteria by modifying the state of chromatin. Here, we review recent evidence supporting the contributory role of such endogenous microbes in disrupting HIV latency and its potential link to the clinical progression of AIDS.

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