Mucosal IgG Levels Correlate Better with Respiratory Syncytial Virus Load and Inflammation than Plasma IgG Levels | Zendy

Marloes Vissers | Zendy; Inge M. L. Ahout | Zendy; Marien I. de Jonge | Zendy; Gerben Ferwerda | Zendy

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Mucosal IgG Levels Correlate Better with Respiratory Syncytial Virus Load and Inflammation than Plasma IgG Levels

Author(s) -

Marloes Vissers,

Inge M. L. Ahout,

Marien I. de Jonge,

Gerben Ferwerda

Publication year - 2015

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00590-15

Subject(s) - inflammation , immunoglobulin a , immunology , immunoglobulin g , respiratory system , virus , virology , covid-19 , medicine , antibody , disease , infectious disease (medical specialty)

Maternal vaccination is currently considered a strategy against respiratory syncytial virus (RSV) infections. In RSV-infected infants, high mucosal IgG levels correlated better with reduced RSV load and lower mucosal CXCL10 levels than plasma IgG levels. For future vaccination strategies against RSV, more focus should be on the mucosal humoral immune response.

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