Evaluation of a Multiplex Bead Immunoassay for Determination of Immune Status to Varicella-Zoster Virus in Medical Center Students and Employees | Zendy

Michael J. Loeffelholz | Zendy; Harry E. Prince | Zendy

Open Access

Evaluation of a Multiplex Bead Immunoassay for Determination of Immune Status to Varicella-Zoster Virus in Medical Center Students and Employees

Author(s) -

Michael J. Loeffelholz,

Harry E. Prince

Publication year - 2015

Publication title -

clinical and vaccine immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.649

H-Index - 77

eISSN - 1556-6811

pISSN - 1556-679X

DOI - 10.1128/cvi.00561-14

Subject(s) - immunoassay , multiplex , varicella zoster virus , antibody , medicine , immunofluorescence , virus , indirect immunofluorescence , virology , immunology , biology , bioinformatics

This study evaluated an enzyme immunoassay, a multiplex bead immunoassay (MBIA), and the anticomplement immunofluorescence (ACIF) test for detecting varicella-zoster virus IgG antibodies in sera from medical center students and employees. The agreement between methods was ≥95%. The MBIA was less sensitive than was the ACIF test, with a negative predictive value of 66.7%.

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